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» Gastrointestinal System
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The possibility and probability of a gut-to-brain connection in autism.
Ann Clin Psychiatry. 2009 Oct-Dec;21(4):205-11. The possibility and probability of a gut-to-brain connection in autism. Reichelt KL, Knivsberg AM. Department of Pediatric Research, Rikshospitalet Medical Centre, University of Oslo, Oslo, Norway. karlr@ulrik.uio.no BACKGROUND: We have shown that urine peptide increase is found in autism, and that some of these peptides have a dietary origin. To be ... -
Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms.
Gastrointestinal pathology, characterized by lymphoid nodular hyperplasia and entero-colitis, has been demonstrated in a cohort of children with autistic spectrum disorder (ASD). Systemic and intestinal mucosal immune dysregulation was assessed in ASD children with gastrointestinal (GI) symptoms (n = 18), and typically developing controls (n = 27), including non-inflamed controls (NIC) and inflame... -
Intestinal lymphocyte populations in children with regressive autism: evidence for extensive mucosal immunopathology.
Inflammatory intestinal pathology has been reported in children with regressive autism (affected children). Detailed analysis of intestinal biopsies in these children indicates a novel lymphocytic enterocolitis with autoimmune features; however, links with cognitive function remain unclear. To characterize further, the nature and extent of this disease we examined the mucosal infiltrate using flow... -
Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial.
Perinatal administration of the probiotic Lactobacillus rhamnosus strain GG (ATCC 53103), reduces incidence of atopic eczema in at-risk children during the first 2 years of life (infancy). We have therefore assessed persistence of the potential to prevent atopic eczema at 4 years. Atopic disease was diagnosed on the basis of a questionnaire and a clinical examination. 14 of 53 children receiving l... -
Are there more bowel symptoms in children with autism?
Are there more bowel symptoms in children with autism compared to normal children and children with other developmental and neurological disorders? There is considerable controversy as to whether there is an association between bowel disorders and autism. Using a bowel symptom questionnaire we compared 51 children with autism spectrum disorder with control groups of 35 children from special school...
