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  • Multiple sclerosis treatment considered for Rett Syndrome

    Glatiramer acetate (also known as Copolymer 1, Cop-1, or Copaxone – as marketed by Teva Pharmaceuticals) is an immunomodulator drug currently used to treat multiple sclerosis and is hypothesized to have some possible affect on patients with Rett Syndrome. It was published on October 14th on PubMed by Ben-Zeev B, Aharoni R, Nissenkorn A, Arnon R. that by raising the Brain derived neurotrophic factor (BDNF) in the brains of Rett mice by use of the drug Glatiramer acetate, that the result has a positive outcome and should be considered in further research as a possible treatment for patients who are affected by Rett Syndrome.

    Rett syndrome (RTT) is an X-linked dominant postnatal severe and disabling neurodevelopmental disorder which is the second most common cause for genetic mental retardation in girls and the first pervasive disorder with a known genetic basis. The syndrome is usually caused by mutations in the Methyl CpG binding protein 2 (MECP2) gene on Xq28. Its protein product MeCP2 acts as a transcriptional repressor or activator depending on the target gene associated.

    http://www.ncbi.nlm.nih.gov/pubmed/20951500

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